Helicobacter pylori Urease.
نویسندگان
چکیده
منابع مشابه
Molecular Dynamics Study of Helicobacter pylori Urease
Helicobacter pylori have been implicated in an array of gastrointestinal disorders including, but not limited to, gastric and duodenal ulcers and adenocarcinoma. This bacterium utilizes an enzyme, urease, to produce copious amounts of ammonia through urea hydrolysis in order to survive the harsh acidic conditions of the stomach. Molecular dynamics (MD) studies on the H. pylori urease enzyme hav...
متن کاملA New Role for Helicobacter pylori Urease: Contributions to Angiogenesis
Helicobacter pylori is a pathogen involved in gastric diseases such as ulcers and carcinomas. H. pylori's urease is an important virulence factor produced in large amounts by this bacterium. In previous studies, we have shown that this protein is able to activate several cell types like neutrophils, monocytes, platelets, endothelial cells, and gastric epithelial cells. Angiogenesis is a physiol...
متن کاملHelicobacter pylori containing only cytoplasmic urease is susceptible to acid.
Helicobacter pylori, an important etiologic agent in a variety of gastroduodenal diseases, produces large amounts of urease as an essential colonization factor. We have demonstrated previously that urease is located within the cytoplasm and on the surface of H. pylori both in vivo and in stationary-phase culture. The purpose of the present study was to assess the relative contributions of cytop...
متن کاملHelicobacter pylori Urease Activity is Influenced by Ferric Uptake Regulator
PURPOSE The role of the Ferric Uptake Regulator (FUR) in the acid resistance of Helicobacter pylori (H. pylori) has been thought to be independent of urease. However, we demonstrated in this study that Fur influences urease activity. MATERIALS AND METHODS A fur knockout mutant of H. pylori was constructed by replacing the Fur gene with a kanamycin resistant marker gene. The wild-type H. pylor...
متن کاملHelicobacter pylori urease significantly reduces opsonization by human complement.
The role of Helicobacter pylori urease in opsonization by human complement was investigated. H. pylori wild type strain N6 and isogenic mutants lacking either the large urease subunit (UreB) or an accessory urease protein (UreG) were incubated with different sera. C3b bound to the bacteria was measured by specific staining and flow cytometry. As compared with opsonization of N6 and the UreG-lac...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 1995
ISSN: 1882-4110,0021-4930
DOI: 10.3412/jsb.50.961